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I general I'd say I agree 98% with Grandy's post above.
a ball of vacuum inside an air-filled room
I don't think that's how Physics works.
Why not? I mean, if all matter can curl up in balls in the middle of space, why can't space curl up in balls in middle of matter?
You can't just instantly make a vacuum, it's a gradual process which involves sucking the air out of whatever airtight container it's being made in - be it a jar or a room. If you turn on your vacuum machine, air is sucked in, and the level of air in the environment equalises to prevent pressure differences. It works similar to osmosis with water. Air cannot support a vacuum within itself because of this. Only a solid (or possibly liquid) container can do that.Turn on your vacuum machine, and the air pressure in the room or jar gradually drops, until the room or jar is empty of air. There is no "ball of vacuum".
Well, suppose a ball of vacuum inside of something solid then, sheesh. Point is it's the lack of something, and since it's the lack of something and we need to name it "The lack of something", it automatically becomes a thing.
So a jar with no air pressure etc = a jar of nothing. Thus, Grandy wins.