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And I think the Mother series is big in Japan.
Same here, the man deserves it. Megiddo or whatever it is can be his final smash. Nobody wants to get hit by that thing... Nobody...
Grand Gaia would probably be way overpowered since I imagine it would affect the whole battlefield. Still, would be cool to see. Problem with that is that it's not specific to Isaac like Ragnarok and Odyssey are. My money would be on Ragnarok just because of how recognizable it is even to non-GS fans.