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Why don't you just use one of the much faster combos like Beacon of Immortality + False Cure? It's much easier to play two instant/sorceries than to play a lot of Zubera's and then kill them with an expensive mass destuction spell.
And the other combo kills the opponent no matter how much life he has, he could have 150 life he'd still die and it's not damage but lose life so he can't prevent it.